Where is the “SARS-COV-2” Animal Model???

In order to determine the pathogenicity of a “virus,” animal models must be employed to see if the supposed pathogen said to be hiding in the toxic cell culture soup actually causes the same disease in healthy animals as it does in humans. However, here we are nearly two years into this “pandemic” and they still have yet to find a suitable animal model that exhibits the same disease as seen in humans. A few recent sources highlight this problem:

From March 17th, 2021:

COVID-19 highlights the model dilemma in biomedical research

Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research.”

Animal models are imperative in preclinical research; however, most animal models are poorly predictive of human conditions. The lack of appropriate models often results in poor clinical outcomes and high failure rates of clinical trials1. In an effort to overcome this translational gap, many researchers are calling for a paradigm shift towards human-centred approaches. However, human-based models do not (yet) emulate complex human (patho)physiological processes and, thus, cannot simply replace animal models.”

“This prompted the World Health Organization to form an international panel to establish suitable animal models for vaccine and therapy testing, with the first summary report published in autumn 20202. One take-home message of this report is that no animal model tested thus far entirely reflects human COVID-19.”

https://www.nature.com/articles/s41578-021-00305-z

From April 2nd, 2021:

Animal models for SARS-Cov2/Covid19 research-A commentary

There is an urgent need for new animal models of SARS CoV-2 infection to improve research and drug development. This brief commentary examines the deficits of current models and proposes several improved alternates. The existing single transgene mouse models poorly mimic the clinical features of COVID-19; those strains get a milder disease than human COVID-19 disease.”

“The current worldwide pandemic is now in its third wave, and worldwide efforts to produce therapeutic solutions are making progress. However, that progress is hampered by the currently available animal models.”

Suitable animal models are essential for understanding aspects of disease pathogenesis and for evaluating the safety and efficacy of vaccine candidates, antibody candidates, or antiviral compounds. A comprehensive review was recently published by Ehaideb et al., [10][24][25] that surveyed publications that reported data on SARS CoV-2 infections in a variety of animals. These included hamsters, non-human primates (macaques), mice, rats, ferrets, rabbits, and cats. All supported viral replication in the lung with mild disease ensuing as assessed by tissue pathology. No animals developed the severe symptoms seen in humans although a transient inflammation was observed inconsistently in non-human primates, hamsters and mice (see below). No cytokine stormscoagulopathy, hypoxemic respiratory failure, multiple organ failure or death were reported.”

https://www.sciencedirect.com/science/article/pii/S0006295221001398

It is clear that they have been unable to replicate the same disease symptoms associated with “Covid-19” as seen in humans when injecting animals experimentally with toxic cell culture supernatant. Thus, they can not claim that they have proven pathogenicity as so far they have failed all of Kochs Postulates including purification/isolation of a “virus” and especially Postulates 3 and 4 in regards to animal models:

  1. The cultured microorganism should cause the SAME DISEASE when introduced into a healthy organism.
  2. The microorganism must be reisolated from the inoculated, diseased experimental host and identified as being IDENTICAL to the original specific causative agent

Why is it that they are having so much trouble finding a suitable animal model to recreate the exact same disease as seen in humans? Were there not numerous reports of many animals testing positive for “SARS-COV-2?” Surely one of these animals said to have had “Covid-19” could be studied seeing as they were already determined to have caught the disease from humans.

Published April 17th, 2021:

Current Status of Putative Animal Sources of SARS-CoV-2
Infection in Humans: Wildlife, Domestic Animals and Pets

“Overall, current data indicate that the most at-risk interactions between humans and animals for COVID-19 infection are those involving certain
mustelids (such as minks and ferrets), rodents (such as hamsters), lagomorphs (especially rabbits), and felines (including cats). Therefore, special attention should be paid to the risk of SARS-CoV-2 infection associated with pets.”

The extent of the COVID-19 pandemic in wild animals is challenging to evaluate and remains largely uncharacterised. Although most domestic animals do not appear to be highly susceptible to SARS-CoV-2, the risk associated with pet ownership should be better defined. Many animals (including some mustelids, rodents, and lagomorphs) are highly susceptible to SARS-CoV-2. Finally, since a large proportion of the human population has been or will be infected with SARS-CoV-2, there is a significant concern about reverse zoonosis, i.e., the spread of this virus from infected humans to naïve domestic or wild animals.”

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.mdpi.com/2076-2607/9/4/868/pdf&ved=2ahUKEwiB2KbgwfHwAhUH-Z4KHX6kDUQQFjAPegQIBxAC&usg=AOvVaw0Bb6E8C6DuqGpPiH2euiVx

Here is some information on animal susceptibility to “SARS-COV-2” according to the CDC, which last updated the page on August 5th, 2021. When I originally wrote this, the version I used was last updated by the CDC on March 25th, 2021. I have included the newly edited out information in italics:

Risk of animals spreading SARS-CoV-2 to people

Some coronaviruses that infect animals can be spread to people and then spread between people, but this is rare. This is what happened with SARS-CoV-2, which likely originated in bats. Early reports of infections were linked to a live animal market in Wuhan, China, but the virus is now spreading from person to person.”

“Reports of animals infected with SARS-CoV-2 have been documented around the world. Most of these animals became infected after contact with people with COVID-19, including owners, caretakers, or others who were in close contact. We don’t yet know all of the animals that can get infected. Animals reported infected include:

  • Companion animals, including pet cats and dogs and one ferret.
  • Animals in zoos and sanctuaries, including several types of big cats, otters, and non-human primates.
  • Mink on mink farms.
  • Wild white-tailed deer in several U.S. states.

Based on the available information to date, the risk of animals spreading COVID-19 to people is considered to be low. More studies are needed to understand if and how different animals could be affected by SARS-CoV-2.

We are still learning about this virus, but we know that it can spread from people to animals in some situations, especially during close contact.”

We know that companion animals like cats and dogs, big cats in zoos or sanctuaries, gorillas in zoos, mink on farms, and a few other mammals can be infected with SARS-CoV-2, but we don’t yet know all of the animals that can get infected. There have been reports of animals infected with the virus worldwide. Most of these animals became infected after contact with people with COVID-19.

A small number of pet cats and dogs have been reported to be infected with SARS-CoV-2 in several countries, including the United States. One ferret was reported positive for SARS-CoV-2 in Slovenia.

Several animals in zoos and sanctuaries have tested positive for SARS-CoV-2, including big cats (lions, tigers, pumas, cougars, snow leopards) and non-human primates (gorillas) after showing signs of illness. It is suspected that these animals became sick after being exposed to an animal caretaker with COVID-19. In many situations, this happened despite the staff wearing personal protective equipment and following COVID-19 precautions.”

SARS-CoV-2 has been reported in mink on farms in multiple countries external icon, including the United States.”

“Recent experimental research shows that many mammals, including cats, dogs, bank voles, ferrets, fruit bats, hamsters, mink, pigs, rabbits, racoon dogs, tree shrews, and white-tailed deer can be infected with the virus. Cats, ferrets, fruit bats, hamsters, racoon dogs, and white-tailed deer can also spread the infection to other animals of the same species in laboratory settings.

A number of studies have investigated non-human primates as models for human infection. Rhesus macaques, cynomolgus macaques, baboons, grivets, and common marmosets can become infected with SARS-CoV-2 and become sick in a laboratory setting. There is some evidence suggesting that laboratory mice, which could not be infected with original strains of SARS-CoV-2, can be infected with new virus variants.

(Labratory mice) Chickens and ducks do not seem to become infected or spread the infection based on results from studies.

These findings were based on a small number of animals, and do not show whether animals can spread infection to people. More studies are needed to understand if and how different animals could be affected by COVID-19.

https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/animals.html

From these two sources, it appears that many animals are said to get “infected” with “SARS-COV-2.” This raises the questions:

  1. Where are all of the outbreaks of “Covid-19” in the animal population?
  2. If humans are transmitting “Covid-19” to animals, what stops the animals from transmitting it right back?
  3. Why are none of these animals suitable as an animal model to reproduce the same disease as seen in humans when they were apparently infected with “SARS-COV-2” from humans?

We are almost two years into this mess and we lack suitable animal models to study this “virus” and prove its pathogenicity. The current best fit is genetically altered transgenic mice as regular mice are not susceptible to infection. It shouldn’t be hard for them to find a suitable host. They have stated all of these animals can be “infected:”

  1. Cats
  2. Dogs
  3. Bank voles
  4. Ferrets
  5. Fruit bats
  6. Hamsters
  7. Mink
  8. Pigs
  9. Rabbits
  10. Racoon dogs
  11. Tree shrews
  12. White-tailed deer
  13. Rhesus macaques
  14. Cynomolgus macaques
  15. Baboons
  16. Grivets
  17. Common marmosets
  18. Lions
  19. Tigers
  20. Pumas
  21. Cougars
  22. Snow leopards
  23. Gorillas
  24. Goats

It seems that there are many animals to choose from that are apparently able to be infected with “SARS-COV-2” yet no suitable animal model exists. Why could this be?

Maybe testing animals and labelling them positive for “SARS-COV-2” with inaccurate, faulty, not-to-be-used-for-diagnosis PCR tests really does show the results are meaningless? Maybe these results help to show how we have a TESTING PANDEMIC rather than a “viral” one?

Makes sense when you think of all the other interesting items testing positive by PCR for “SARS-COV-2:”

  • Pawpaw fruit
  • Motor oil
  • Coca Cola
  • Chicken wings
  • A salmon cutting board
  • Ice cream
  • Water
  • Healthy people… 🤔

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